Use and cardiovascular safety of transdermal and other granisetron preparations in cancer management
نویسندگان
چکیده
5-HT3 antagonists have been available as oral and intravenous preparations for decades. The availability more recently of transdermal granisetron and the anticipated availability of a subcutaneous granisetron preparation have provided helpful alternatives to patients, and these preparations have been shown to have less potential to prolong QT than other drugs in the class.
منابع مشابه
Use of granisetron transdermal system in the prevention of chemotherapy-induced nausea and vomiting: a review
Until now only intravenous and oral formulations of 5HT(3) receptor antagonists have been available. Recently a new formulation of a 5HT(3) receptor antagonist, transdermal granisetron, has been developed, and approved by the FDA. Three phase I studies to evaluate its pharmacokinetic profile have shown that granisetron administered by a transdermal delivery system is absorbed by passive diffusi...
متن کاملEnhanced Transdermal Delivery of Granisetron by Using Iontophoresis
The purpose of the present study was to explore the passive and electrically assisted transdermal transport of Granisetron hydrochloride (GRA) in solution and gel formulation through iontophoresis and also the feasibility of delivering therapeutic amounts of drug for the treatment of chemotherapy-induced nausea and vomiting. In this study, iontophoretic permeation of GRA through guinea pig...
متن کاملGranisetron transdermal system: a new option to help prevent chemotherapy-induced nausea and vomiting.
Transdermal medication delivery systems provide systemic therapy by passive diffusion through the skin. They offer an alternative route of medication administration and may be well suited for patients who are unable to take or retain oral medications. Granisetron transdermal system (Sancuso(R), ProStrakan, Inc.) is the first transdermal medication patch indicated for the prevention of nausea an...
متن کاملEnhanced Transdermal Delivery of Granisetron by Using Iontophoresis
The purpose of the present study was to explore the passive and electrically assisted transdermal transport of Granisetron hydrochloride (GRA) in solution and gel formulation through iontophoresis and also the feasibility of delivering therapeutic amounts of drug for the treatment of chemotherapy-induced nausea and vomiting. In this study, iontophoretic permeation of GRA through guinea pig...
متن کاملUse of transdermal and intravenous granisetron and the ability of the Hesketh score to assess nausea and vomiting induced by multiday chemotherapy
PURPOSE Hesketh scores define emetogenicity of single-agent and multiagent single-day chemotherapy. This analysis determined the emetogenicity of multiagent, multiday chemotherapy and the Granisetron Transdermal System (GTDS; Sancuso(®)). METHODS This was a retrospective analysis of a multicenter, randomized, double-blind, phase III noninferiority trial of GTDS versus oral granisetron in pati...
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